What Causes Lupus?
I got my 3rd comment and this one came with some questions. "How could we possibly cure this kind of disease? Any answers? I just want to be aware of this and in some instances avoid from having lupus."
Since there is no cure for lupus, in my opinion, we need to figure out why we get lupus before we can find a cure for it.
I have a basic understanding of the most accepted theories for what causes lupus but I wanted to give you as detailed an answer as possible so I researched it a bit and this is some good informatiion on the suspected causes of lupus.
This came from the Cleveland Clinic:
What Causes Lupus?
The cause of systemic lupus erythematosus (SLE or lupus) is unknown. Finding the cause is the object of major research efforts.
Factors that may contribute to the cause of lupus include viruses, environmental chemicals and the person's genetic makeup.
Female hormones are believed to play a role in the development of lupus because women are affected more commonly than men. This is especially true of women during their reproductive years, a time when hormone levels are highest.
The observation that lupus may affect more than one member of the same family has raised the possibility that the tendency to develop lupus may be inherited. Having such a tendency, however, does not predict that a relative will develop lupus. About 10 percent of lupus patients have a close relative with lupus
They have a lot of theories but don't have anything definitive. "Viruses, environmental chemicals, genetic makeup, hormones," they cover everything. BUT I think the future is so promising. In my opinion, Benlysta will be approved this year and will do phenominal because all rheummy's will try their patients on it if they feel they qualify for it. There has not been a drug approved for lupus in over 50 years. Once Human Genome Sciences receives FDA approval and their stock jumps, yes - I own a little of it and it has been fun watching it jump (HGSI is their stock symbol if you want to check the company out). I only have a little money in there (oh how I wish I had invested more
but I still think it is going to jump again once they get FDA approval. I should be saying if they get FDA approval but I don't talk that way. There is too much riding on this for us luppies walking around immmunosupressed terrified of getting sick. We need better drugs to help us get through the day and give us back a little of who we were before lupus reaked havoc on our life, our families, our body,our spirit, okay, I'll stop now. Again, I am not a doctor, but I think it only immunosupresses B cells instead of our whole body like the lupus drugs used today do.
Now for my opinion based on no medical expertise If you feel you might be predisposed to SLE because someone in your family has lupus or you have some of the symptoms but not enough to be diagnosed, I would suggest ALWAYS wear SPF 30 or up even on cloudy days. Only fake tans and when you look so HOT at 50 because you don't have lots of wrinkles, you'll be so happy you were vigilant in your younger years. Get a healthy amount of sleep about 7 to 8 hours whenever possible.. Eat well and treat your body well, like that saying your body is your temple. If you don't feel very good and can afford to, take a sick day or cancel on your friends, true friends will understand. And if you feel tired to the bone, muscle weakness (like it hurts to blow dry your hair or dress yourself or your kids), get rashes and/or sick when you go out in the sun, then I would meet with your doctor, discuss your concerns and ask him to run an ANA test and anything else he recommends initially. I will post the criteria for diagnosing lupus either today or tomorrow which will be helpful too. Thanks for the comment & questions, sweetie. Feel free to email me lupuscelebrity@gmail.com or post any other questions.
So anyway, once Benlysta is out and the majority of rheummies are prescribing it to their lupus patients and the company's profitability rises, their stock rises, other drug companies will want a piece of the market . These other drug companies will hopefully dedicate more $ to research and development so they can release the next big lupus drug, then the 3rd and on and on. It is a huge market of people with lupus, mctd (mixed connective tissue disease), Sjogrens Syndrome, and fibromyalgia and many of these people have many lupus symptoms . This is our year & our decade, my friends. I even had 2 friends mention they saw a lupus commercial on tv. I was thrilled!
Now whose going to be the first to subscribe so you are notifed when I update the blog.? And please keep the comments coming, I need them to mentally keep going with this thing. I am tired all the time but I love sharing my life and lupus news with all of you. But I have to know I am reaching people. I know, I am SO high maintenance, haha. Sweet dreams.
xoxo
Lupus Celebrity
Since there is no cure for lupus, in my opinion, we need to figure out why we get lupus before we can find a cure for it.
I have a basic understanding of the most accepted theories for what causes lupus but I wanted to give you as detailed an answer as possible so I researched it a bit and this is some good informatiion on the suspected causes of lupus.
This came from the Cleveland Clinic:
What Causes Lupus?
The cause of systemic lupus erythematosus (SLE or lupus) is unknown. Finding the cause is the object of major research efforts.
Factors that may contribute to the cause of lupus include viruses, environmental chemicals and the person's genetic makeup.
Female hormones are believed to play a role in the development of lupus because women are affected more commonly than men. This is especially true of women during their reproductive years, a time when hormone levels are highest.
The observation that lupus may affect more than one member of the same family has raised the possibility that the tendency to develop lupus may be inherited. Having such a tendency, however, does not predict that a relative will develop lupus. About 10 percent of lupus patients have a close relative with lupus
They have a lot of theories but don't have anything definitive. "Viruses, environmental chemicals, genetic makeup, hormones," they cover everything. BUT I think the future is so promising. In my opinion, Benlysta will be approved this year and will do phenominal because all rheummy's will try their patients on it if they feel they qualify for it. There has not been a drug approved for lupus in over 50 years. Once Human Genome Sciences receives FDA approval and their stock jumps, yes - I own a little of it and it has been fun watching it jump (HGSI is their stock symbol if you want to check the company out). I only have a little money in there (oh how I wish I had invested more
but I still think it is going to jump again once they get FDA approval. I should be saying if they get FDA approval but I don't talk that way. There is too much riding on this for us luppies walking around immmunosupressed terrified of getting sick. We need better drugs to help us get through the day and give us back a little of who we were before lupus reaked havoc on our life, our families, our body,our spirit, okay, I'll stop now. Again, I am not a doctor, but I think it only immunosupresses B cells instead of our whole body like the lupus drugs used today do.Now for my opinion based on no medical expertise
If you feel you might be predisposed to SLE because someone in your family has lupus or you have some of the symptoms but not enough to be diagnosed, I would suggest ALWAYS wear SPF 30 or up even on cloudy days. Only fake tans and when you look so HOT at 50 because you don't have lots of wrinkles, you'll be so happy you were vigilant in your younger years. Get a healthy amount of sleep about 7 to 8 hours whenever possible.. Eat well and treat your body well, like that saying your body is your temple. If you don't feel very good and can afford to, take a sick day or cancel on your friends, true friends will understand. And if you feel tired to the bone, muscle weakness (like it hurts to blow dry your hair or dress yourself or your kids), get rashes and/or sick when you go out in the sun, then I would meet with your doctor, discuss your concerns and ask him to run an ANA test and anything else he recommends initially. I will post the criteria for diagnosing lupus either today or tomorrow which will be helpful too. Thanks for the comment & questions, sweetie. Feel free to email me lupuscelebrity@gmail.com or post any other questions.So anyway, once Benlysta is out and the majority of rheummies are prescribing it to their lupus patients and the company's profitability rises, their stock rises, other drug companies will want a piece of the market . These other drug companies will hopefully dedicate more $ to research and development so they can release the next big lupus drug, then the 3rd and on and on. It is a huge market of people with lupus, mctd (mixed connective tissue disease), Sjogrens Syndrome, and fibromyalgia and many of these people have many lupus symptoms . This is our year & our decade, my friends. I even had 2 friends mention they saw a lupus commercial on tv. I was thrilled!
Now whose going to be the first to subscribe so you are notifed when I update the blog.? And please keep the comments coming, I need them to mentally keep going with this thing. I am tired all the time but I love sharing my life and lupus news with all of you. But I have to know I am reaching people. I know, I am SO high maintenance, haha. Sweet dreams.
xoxo
Lupus Celebrity
Posted by lupuscelebrity at 1/17/2010 1:45 AM 
Categories: FDA approval, HGSI, lupus celebrity, lupus, environmental chemicals
Tags: FDA approval sun lupus human Genome Sciences Inc genetic makeup SPF hormones reproductivem inherited cleveland clinic lupus celebrity sle environmental chemicals viruses HGSI
Categories: FDA approval, HGSI, lupus celebrity, lupus, environmental chemicals
Tags: FDA approval sun lupus human Genome Sciences Inc genetic makeup SPF hormones reproductivem inherited cleveland clinic lupus celebrity sle environmental chemicals viruses HGSI
Thanks for writing about Benlysta. I too am a stockholder of HGSI and got in before the July 20 results. I "bet the farm" so to speak and have done very well since the $3 per share that it was prior to July 20, and has now hit over $30 per share! I guess we're not the only ones who did our due diligence and had all the faith in the world with Human Genome Scienes and Benlysta! Benlysta has met all it's primary endpoints in all the trials (BLISS 52 and BLISS 76) and HGSI is planning on submitting for FDA approval in 2Q 2010. At the very earliest, we could feasably see approval late this year, in my opinion. When they did the Phase 3 trials, they were done with an FDA SPA (Special Protocol Assessment) agreement. This means that these trials were designed in conjunction with the FDA and their guidelines and which puts Benlysta at having a better chance to be "fast tracked" since there is no other comparable drug for Lupus AND there is a huge unmet physical need, for this drug. The FDA uses these two guidelines when determining if the drug should receive fasttrack status towards approval. The last drug that was approved for Lupus was over 50 years ago! Now I'd say, we definately have an "unmet medical need"!!!!
Since the trial was designed, along side the FDA, it could help to eliminate many/some of the usual "surprises" that can come about in the approval process. I have been a sufferer of Lupus since 2001 and was finally diagnosed in 2004. I'm so thrilled at the possiblity of Benlysta!!!! A new chance at life! Originally, the trial failed, but when HGSI took a closer look at the trial results, they discovered a subset of patients that it DID work on and worked very well, and since that "failure" of sorts happened, it paved the way for discoving, just how to do a successful Lupus trial. Human Genome Sciences has been touted as to "cracking the code" so to speak, when they discovered this subset of patients and how to successfully design a trial for Lupus. Now, if we could only get one of these companies, to design a quick bloodtest, specifically for diagnosing Lupus. I know, I'm asking for a lot now LOL!!! HGSI has stated that it could cost about $20,000+ per year. The CEO, Tom Watkins said that if someone needs the drug and cannot afford it, they will make sure that that they get access to it.
Good Luck to all my fellow Lupus sufferers!
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Lupus sometimes seems to run in families, which suggests the disease may be hereditary. Lupus is most common in women between the ages of 15 and 44. Scientists think a woman’s hormones may have something to do with getting lupus. But men and older people also can get it. African American women are three times more likely to get lupus than white women. It’s also more common in Hispanic/Latino, Asian, and American Indian women.
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Although i'm a huge advocate for tanning, I must say, when one chooses to do things that have serious risks attached, they must be prepared for that. I tan 3 times a week, and know that there is probably a good chance of me getting skin cancer, which is unfortunate. However, it's one of those things where I am caught up in the moment.
In terms of being in the sun, it is super important to wear SPF at all times. Most people are unaware that when it is overcast - you get just as much, if not more sun. Therefore, you need just as much, if not more, protection!
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